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Keep an eye on Closely (one)pentobarbital will reduce the extent or influence of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to some minimize in fentanyl plasma concentrations, deficiency of efficacy or, perhaps, improv